Changes in C19-Steroid Metabolism by Ovine Placentas During Cortisol Administration1
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چکیده
منابع مشابه
Steroid metabolism in guinea pigs. I. Metabolism of cortisol in vivo.
In previous studies (l-3) cortisol (hydrocortisone) was isolated and identified from the urine of the normal and the scorbutic guinea pig. However, paper partition chromatography of extracts of guinea pig urine (2) revealed that in addition to cortisol several other blue tetrazolium-reducing steroids were present. The possibility existed that some of these steroids were metabolites of endogenou...
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BACKGROUND Critical illness is often accompanied by hypercortisolemia, which has been attributed to stress-induced activation of the hypothalamic-pituitary-adrenal axis. However, low corticotropin levels have also been reported in critically ill patients, which may be due to reduced cortisol metabolism. METHODS In a total of 158 patients in the intensive care unit and 64 matched controls, we ...
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James I. %Vessel, B.S.; and Brandon Taylor, B.S. G lucocorticoids have been recognized to play an important role in lung development in utero.’ The identification of specific receptors for cortisol in both the cytosol and nuclear fraction of fetal lung homogenates supports the concept that the lung is an important target tissue for this steroid.2.3 Administration of cortisol to rabbit fetuses a...
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The incorporation of (14)C-labelled myristic, palmitic, stearic, oleic and linoleic acids in vitro into the lipids of bovine spermatozoa was measured at intervals from 2min to 2h. All acids were rapidly incorporated into diglycerides, myristic acid being metabolized to the greatest extent. Whereas the low incorporation of acids into total phospholipids reflected the relative stability of the ma...
متن کاملCortisol Metabolism
Cortisol is the principal glucocorticoid hormone in humans, contributing to homeostatic regulation of basal metabolism and salt and water balance, and modulating the response to stress. Normal adult human adrenal glands secrete around 5—15mg per day of cortisol. Only a small fraction is excreted as free cortisol in urine, saliva or bile. The rest is cleared by several metabolic pathways before ...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1978
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod18.4.643